Antigen Preparation
"A synthetic peptide corresponding to the internal region of human FOXP2 protein. This sequence is identical to human, mouse, rat and dog"
Background
"Forkhead/winged-helix box (Fox) genes are the transcriptional regulators and highly conserved across mammals. It contains a FOX DNA-binding domain and large polyglutamine tract. The FOXPs are involved in organogenesis and cell differentiation. FOXP2 gene encodes an evolutionarily conserved transcription factor expressed in fetal and adult brain. A mutation of FOXP2 was discovered in patients with severe defects in speech and language, such as speech disorder, autism."
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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