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SOCS-4

Suppressor of Cytokine Signaling 4 (SOCS4); SOCS7

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Antigen Preparation

"A synthetic peptide corresponding to the C-terminus of SOCS-4 protein from human, mouse and rat origins."

Background

"Cytokines induce a variety of biological responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways which are suppressed by other transcriptional factors. Proteins that mediate these signals from the cell surface to the nucleus include JAKs and STATs, while SOCS (Suppressor of cytokine signaling) proteins inhibit those signaling. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS4, SOCS6 and SOCS7 are expressed ubiquitously in murine tissues. "

PURIFICATION The Rabbit IgG is purified by Epitope Affinity Purification	SPECIFICITY This antibody recognizes ~50 kDa of SOCS-4 protein from human and mouse origins. The other species are not tested.
FORMULATION This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.	STORAGE The antibodies are stable for 12 months from date of receipt when stored at –20oC. The antibodies can be stored at 2oC-8oC for one month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Gene ID

122809

Applications/Suggested Working Dilutions

Western Blot

0.1-1 µg/ml

ELISA

0.01-0.1 µg/ml

Immunoprecipitation

2-5 µg/ml

IHC

2-10 µg/ml

Flow cytometry

Not tested

Order Info

Catalog #:	500-10164
Lot #:
Size:	100ug/200ul
Host:	Rabbit
Clone:	N/A
Isotyping:	Rabbit IgG
Applications:	WB
Reactivity:	Hu
Price:	$ 215.00

REFERENCES

"Bullock, AN et al. Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation. Structure, 2007 Nov;15(11):1493-504."