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SH3BP5(pS424)

SAB; SH3BP-5

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Antigen Preparation

A synthetic phosphospecific peptide QSST-S*-LESQ

Background

"SH3BP5, SH3-domain binding protein 5 (BTK-associated) is a encoded protein by the SH3BP5 gene. The expression of SH3BP5 was enhanced in acute myeloid leukemia (AML) cells and was negatively correlated with patients survival. Elevated expression of SH3BP5 was an independent prognostic factor for AML patients. Furthermore, the phosphorylation of SH3BP5-mediated activation of JNK-BAD signaling contributes to the survival of AML cells."

PURIFICATION The Rabbit IgG is purified by site-modified Epitope Affinity Purification.	SPECIFICITY This antibody recognizes phosphorylated Serine 424 of mouse SH3NP5 protein (QSSTSLESQ). It does not recognize the non-phosphorylated SH3BP5 or other phosphorylation sites.
FORMULATION 25mM Tris-Buffered Saline (pH7.2-7.8) with 0.01% NaN3 + antibody stabilizer	STORAGE The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Gene ID

9467

Applications/Suggested Working Dilutions

Western Blot

0.1-1 µg/ml

ELISA

0.01-0.1 µg/ml

Immunoprecipitation

2-5 µg/ml

IHC

2-10 µg/ml

Flow cytometry

5-10 µg/10^6 cells

Order Info

Catalog #:	631-040
Lot #:
Size:	100ug/200ul
Host:	Rabbit
Clone:	N/A
Isotyping:	Rabbit IgG
Applications:	"IHC(P), WB"
Reactivity:	"Hu, Ms, Rt"
Price:	$ 245.00

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