Antigen Preparation
Recombinant protein of human CD206
Background
"CD206, also known as Macrophage Mannose Receptor (MMR) or mannose receptor (MR), is a 162-175 kD type I membrane protein that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is expressed on macrophages, dendritic cells, and hepatic or lymphatic endothelial cells, but not on monocytes. CD206 recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine. Ir plays an important role in host defense, and provides a link between innate and adaptive immunity"
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
5-10 µg/10^6 cells
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