Antigen Preparation
"A synthetic peptide EL TSL SDE DSG KGS QPP SPP SP corresponding to human SNAI-1 protein. It is identical to human, mice and rat."
Background
"Snail (SNAI) is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. This proteins regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of Drosophila SNAIL, and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver, and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sna, each contain three classic zinc fingers and one atypical zinc finger. Genetic variants in SNAI and TWIST are associated with breast and ovarian cancers."
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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