Antigen Preparation
A synthetic peptide of human Claudin 5
Background
"Stromal cell-derived factor 1, also known as C-X-C motif chemokine 12 (CXCL12), is a chemokine protein. The protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. CXCR7 and its ligand, chemokine CXCL12, were established to be involved in biological behaviors and associated with prognosis in many cancers. CXCL12-CXCR7 axis contributes to the invasive phenotype of pancreatic cancer. During embryonic development, CXCL12 plays a role in cerebellar formation through the migration of neurons."
Applications/Suggested Working Dilutions
|
|
|
Immunoprecipitation
2-5 µg/ml
|
|
Flow cytometry
Not tested
|