Antigen Preparation
A synthetic peptide of human BCL-XL
Background
"B-cell lymphoma-extra large (Bcl-xL) is a transmembrane molecule in the mitochondria. A growing body of evidence supports a role for mitochondria and mitochondria-derived factors in the cell death process. Bcl-xL is capable of preventing cytochrome c release while also significantly inhibiting cell death. Mitochondrial release of factors such as cytochrome c represents a critical step in committing a cell to death, and this release is independent of permeability transition and caspase activation but is inhibited by Bcl-xL. Bcl-XL plays critical role in cancer development and resistance to treatment. Bcl-XL also protects cancer cells from p53-mediated apoptosis."
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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