Antigen Preparation
A recombinant protein of human CD5
Background
"CD5, a 67 kD protein, is a member of the scavenger receptor cysteine-rich protein superfamily. CD5 is a good marker for T-cells, although not as sensitive as CD3. Since its discovery, CD5 has been used as a marker to identify T cells, B1-a cells, and B cell chronic lymphocytic leukemia cells. Many studies have described the functional relevance of CD5 as a modulator of T and B cell receptor signaling. In recent years CD5 has emerged as a functional receptor in other areas of the immune system. CD5 was found to promote T cell survival by protecting autoreactive T cell from activationâ€induced cell death, to promote de novo induction of regulatory T cells in the periphery, to modulate Th17 and Th2 differentiation, and to modulate immune responses by modulating dendritic cell functions. The newly established roles of CD5 in modulating different aspects of immune responses identify this receptor as an immune checkpoint modulator, and therefore it could be used as a target for immune intervention in different pathologies such as cancer, autoimmune diseases or infections"
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
0.5-5 µg/106 cells
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