Background
"Sox11 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. Sox4 and Sox11 operate downstream from proneural bHLH proteins and are vital for the establishment of pan-neuronal protein expression. Sox11 is also prominently expressed in the neurogenic areas of the adult brain. Sox11 expression is strictly confined to doublecortinâ€expressing neuronally committed precursors and immature neurons . Sox11 is involved in the transcriptional regulation of specific gene expression programs in adult neurogenesis at the stage of the immature neuron. It was shown that de novo SOX11 mutations cause Coffin–Siris syndrome. SOX11 has also been detected in some malignant tumors, including mantle cell lymphoma."
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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