GSK-3alpha
Glycogen Synthase Kinase 3a; GSK3A;
Download Product PDF
MSDS Download Product PDF
Antigen Preparation
"A synthetic peptide corresponding to N-terminus of human GSK3-alpha protein. This sequence is identical among human, mouse and rat."
Background
"Glycogen Synthase Kinase-3 has two isoforms, GSK-3α and GSK3β. GSK3 is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and down-regulating the activity of muscle glycogen synthase as well as the regulation in Wnt signal pathway. GSK-3 alpha reduces the substrates beta-catenin and tau to imply an important role in Wnt signaling and tauopathies such as Alzheimer’s disease.."
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
|
SPECIFICITY
"This antibody recognizes GSK-3 alpha. It reacts with human, mouse and rat. The other species are not tested."
|
FORMULATION
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
|
STORAGE
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
|
Applications/Suggested Working Dilutions
|
|
|
Immunoprecipitation
2-5 µg/ml
|
|
Flow cytometry
Not tested
|