Antigen Preparation
"A synthetic peptide containing - GKYSVKEK- epitope. This sequence is identical to human, mouse, and rat."
Background
"L1 cell adhesion molecule (L1CAM) glycoprotein protein belongs to the immunoglobulin supergene family of cell adhesion molecules (CAM). It consists of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Phosphorylation of L1CAM is involved in nervous system function. "
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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