GLEPP-1
Glomerular Epithelial Protein 1; NPHS6; PTPU2; GLEPP1; PTP-OC;
PTP-U2; PTPROT; R-PTP-O
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Antigen Preparation
The recombinant fusion protein made from part of the extracellular domain of human GLEPP-1.
Background
"Glomerular Epithelial Protein 1 (GLEPP1) is a transmembrane protein tyrosine phosphatase found only in the epithelial cells of the renal glomerulus. It is localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. It may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. GLEPP-1 is present only in visceral glomerular cells (Podocytes). The presence of GLEPP1 may be used as a marker of podocyte integrity in various forms of glomerular injury. "
PURIFICATION
The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
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SPECIFICITY
This antibody recognizes human GLEPP-1 protein. The other species are not tested.
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FORMULATION
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
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STORAGE
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
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Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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