Corin (IN)
Pro-ANP-converting enzyme (Corin), LRP4; CRN;
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Antigen Preparation
A synthetic peptide sequence derived from 300aa-450aa of mouse corin protein.
Background
"Corin, is a glycosylated protease on the cell surface as a single pass type II membrane protein. It is located on trial and brain natriurectic peptides (ANP and NNP) expressing cell surfaces. It may occur in both zymogen and catlytically active forms. The multi-domain transmembrane serine protease corin cleaves pro-atrial natriuretic peptide (pro-ANP) in vitro to generate an active hormone, ANP at R123-S124. Corin is higher expressed on cardiomyocytes. It may also contribute to the regulation of the natriuretic peptide system in vivo, and might be an attractive target for treatment of cardiovascular diseases."
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
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SPECIFICITY
This antibody recognizes ~120 kDa of mouse Corin. It does not reacts with rat. The other species are not tested.
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FORMULATION
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
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STORAGE
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
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Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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