GluR1 (pS863)
Glutamate receptor 1; GLUR1
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Antigen Preparation
A synthetic phosphospecific peptide STLPRN-S*-GAG
Background
"Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptor is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. The level of phosphorylated GluR1 at two major sites implicated in GluR regulation for further research of the mechanisms underlying synaptic plasticity"
PURIFICATION
The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
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SPECIFICITY
This antibody recognizes phosphorylated Serine 863 of human GluR1 protein (STLPRNSGAG). It does not recognize the non-phosphorylated CluR1 or other phosphorylation sites.
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FORMULATION
25mM Tris-Buffered Saline (pH7.2-7.8) with 0.01% NaN3 + antibody stabilizer
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STORAGE
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
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Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
5-10 µg/10^6 cells
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