Antigen Preparation
A synthetic peptide of human Connexin 36
Background
"Connexins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells. Connexins are arranged in groups of 6 around a central pore to form a connexon, a component of the gap junction intercellular channel. Connexin-36 (CX36), is a member of the connexin gene family that is expressed predominantly in mammalian neurons. β-cells of the pancreas also express connexin36. Pancreatic beta cells are connected by gap junction channels made of connexin 36, which permit intercellular exchanges of current-carrying ions (ionic coupling) and other molecules (metabolic coupling).
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Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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