Antigen Preparation
A synthetic peptide of human Cadherine-17
Background
"Cadherin 17 is cadherin-like calcium-dependent, membrane-associated glycoprotein, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. It is expressed on the basolateral surface of enterocytes and goblet cells in the small and large intestine, The protein may also play a role in the morphological organization of liver and intestine. Silencing of cadherin-17 enhances apoptosis and inhibits autophagy in colorectal cancer cells.
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Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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