Antigen Preparation
A recombinant protein of human CD21
Background
"CD21 is a 145 kD membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. CD21 is expressed on B cells, follicular dendritic cells, some epithelial cells, subsets of normal thymocytes and T cells, Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). CD21 and FCRL5 form a receptor complex with robust B-cell activating capacity. Biased expression in lymph node, spleen, and tonsil. CD21 binds to a variety of endogenous ligands, including the complement component C3 fragments iC3b, C3dg and C3d, the low-affinity IgE receptor CD23, and the type I cytokine, interferon-alpha."
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
0.5-5 µg/106 cells
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