Antigen Preparation
A recombinant protein of human CD56
Background
"The neural cell adhesion molecule (NCAM), also known as CD56, is a member of the immunoglobulin superfamily engaged in both so-called homophilic and heterophilic interactions. Three main isoforms exist of CD56 (NCAM-120, NCAM-140, and NCAM-180), all generated by alternative splicing from one single gene, differing in their intracellular domain length. CD56 is often considered a marker of neural lineage commitment due to its discovery site. CD56 expression is also found in the hematopoietic system. The expression of CD56 is most stringently associated with natural killer (NK) cells. CD56 has been detected on other lymphoid cells, including gamma delta (γδ) T cells and activated CD8+ T cells, as well as on dendritic cells (DCs) In the bone marrow, at the site where hematopoiesis occurs, CD56 fulfills a pivotal role. CD56 expression is seen in a range of hematological malignancies as well as solid tumors. "
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
0.5-5 µg/106 cells
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