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CD11c

ITGAX, CD11C; SLEB6

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Antigen Preparation

A recombinant protein of human CD11c

Background

"CD11c is a 145-150 kD type I transmembrane glycoprotein. It is also called ITGAX integrin subunit alpha X. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. CD11c non-covalently associates with integrin Î²2 (CD18) and is expressed on monocytes/macrophages, dendritic cells, granulocytes, NK cells, and subsets of T and B cells. CD11c has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b."

PURIFICATION The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping	SPECIFICITY This antibody recognizes human CD11c protein. The other species are not tested.
FORMULATION This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer	STORAGE The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Gene ID

3687

Applications/Suggested Working Dilutions

Western Blot

0.1-1 µg/ml

ELISA

0.01-0.1 µg/ml

Immunoprecipitation

2-5 µg/ml

IHC

2-10 µg/ml

Flow cytometry

0.5-5 µg/106 cells

Order Info

Catalog #:	605-190
Lot #:
Size:	100ug/200ul
Host:	Mouse
Clone:	3.9
Isotyping:	IgG1
Applications:	IHC(P), FC
Reactivity:	Hu
Price:	$ 245.00

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