Antigen Preparation
A recombinant protein of human CD29
Background
"CD29 (ITGB1), a 130 kD single chain type I glycoprotein, belongs to integrin family. Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. The ITGB1 gene encodes a beta subunit. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Integrins link extracellular matrix with actin cytoskeleton to transmit signals between extracellular matrix and cytoplasmic domains. It was shown that CD73 and CD29 concurrently mediate the mechanically induced decrease of migratory capacity of mesenchymal stromal cells"
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
0.5-5 µg/106 cells
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