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CD117(c-kit) (Ms)

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Antigen Preparation

A recombinant protein of human CD117/c-kit

Background

"CD117, a 145 kD immunoglobulin superfamily member, also known as c-kit and stem cell factor receptor (SCFR) is a transmembrane tyrosine-kinase receptor that binds the c-kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells."

PURIFICATION The Mouse IgG is purified by Affinity Purification	SPECIFICITY This antibody recognizes mouse CD117(c-kit) (Ms) protein. The other species are not tested.
FORMULATION This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer	STORAGE The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Gene ID

Applications/Suggested Working Dilutions

Western Blot

0.1-1 µg/ml

ELISA

0.01-0.1 µg/ml

Immunoprecipitation

2-5 µg/ml

IHC

2-10 µg/ml

Flow cytometry

0.5-5 µg/106 cells

Order Info

Catalog #:	604-530
Lot #:
Size:	100ug/200ul
Host:	Rat
Clone:	2B8
Isotyping:	Rat IgG2b
Applications:	IHC(P), FC
Reactivity:	Ms, Pig
Price:	$ 245.00

REFERENCES

" Ikuta K, et al. 1992. Annu. Rev. Immunol. 10:759."