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CD61(Ms)

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Antigen Preparation

Enriched mouse macrophage

Background

"CD61, also known as integrin Î²3 and glycoprotein IIIa (gpIIIa), is a 90 kD type I integral transmembrane glycoprotein. It is a member of the integrin family, associating with platelet gpIIb (CD41) to form CD41/CD61 complex and with integrin Î±V (CD51) to form Î±V/Î²3 (CD51/CD61) integrin. CD41/CD61 is expressed on platelets and megakaryocytes, and plays a role in platelet activation and aggregation through interaction with fibrinogen, fibronectin, vWF, and other RGD-containing adhesion molecules. CD51/CD61 is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells involved in tumor metastasis, and in adenovirus infection through binding to RGD motif in extracellular matrix proteins"

PURIFICATION The Mouse IgG is purified by Affinity Purification	SPECIFICITY This antibody recognizes human mouse CD61(Ms) protein. The other species are not tested.
FORMULATION This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer	STORAGE The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.

Gene ID

Applications/Suggested Working Dilutions

Western Blot

0.1-1 µg/ml

ELISA

0.01-0.1 µg/ml

Immunoprecipitation

2-5 µg/ml

IHC

2-10 µg/ml

Flow cytometry

0.5-5 µg/106 cells

Order Info

Catalog #:	604-510
Lot #:
Size:	100ug/200ul
Host:	Rat
Clone:	HMB3
Isotyping:	IgG1
Applications:	IHC(P), FC
Reactivity:	Hu
Price:	$ 245.00

REFERENCES

"Roberts M, et al. 2004. Mol. Cell. Biol. 24:1505."