Antigen Preparation
A recombinant protein of human CD36
Background
"CD 36 is a member of the class B scavandor receptor family of cell surface proteins. The molecular mass of the functional receptor is 78–88 kDa, depending on the cell type and on post-translational glycosylations. The receptor consists of 1 extracellular, 2 transmembrane, and two cytoplasmic fragments representing the C-terminal and N-terminal parts of the molecule. CD36 is present on the surface of platelets, endothelial cells, macrophages, dendrite cells, adipocytes, striated muscle cells, and hematopoietic cells. It binds thrombospondin, long chain fatty acids, phospholipids, collagen type I, IV, and V , apoptotic cells, oxidized and naïve lipoproteins. It also It imports fatty acids inside cells. Defective CD36 is a likely candidate gene for impaired fatty acid metabolism, glucose intolerance, atherosclerosis, arterial hypertension, diabetes, cardiomyopathy, Alzheimer disease, and modification of the clinical course of malaria."
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
0.5-5 µg/106 cells
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