Antigen Preparation
A recombinant protein of CD134 protein
Background
"The protein CD134, tumor necrosis factor receptor superfamily, member 4 (TNFRSF4) is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. Studies show that high OX40 (CD134) expression in the tumor immune infiltrate is a favorable prognostic factor of overall survival in non-small cell lung cancer."
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
0.5-5 µg/106 cells
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