TGF alpha
Transforming growth factor, alpha
Download Product PDF
MSDS Download Product PDF
Antigen Preparation
a recombinant protein of 50 aa TGF-alpha
Background
"Transforming growth factor alpha (TGF-α) is a member of the epidermal growth factor family. It is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. TGF-α binding to EGFR promotes cell proliferation events that include wound healing and embryogenesis. TGF-α is also implicated in tumerogenesis and angiogenesis. It promotes tumorigenesis and regulates epithelial-mesenchymal transition modulation in colon cancer. TGFα has an higher expression in hepatocyte regeneration and proliferation in cirrhotic livers than in hepatocellular carcinoma."
PURIFICATION
The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
|
SPECIFICITY
This antibody recognizes human TGF alpha protein. The other species are not tested.
|
FORMULATION
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
|
STORAGE
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
|
Applications/Suggested Working Dilutions
|
|
|
Immunoprecipitation
2-5 µg/ml
|
|
Flow cytometry
Not tested
|