Beta-Tubulin III
beta tubulin III, : CDCBM; FEOM3; TUBB4; CDCBM1; CFEOM3; beta-4; CFEOM3A, TUBB3
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Antigen Preparation
A Synthetic peptide sequence corresponding to the C-terminus of human beta-Tubulin-III.
Background
"Tubulin III is a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. Beta tubulin is expressed in some malignant tissues including a subgroup of colorectal neoplasms, ovarian cancer, etc. Together with LncRNA RPPH1 it promotes colorectal cancer metastasis "
PURIFICATION
The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
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SPECIFICITY
This antibody recognizes human Beta-Tubulin III protein. The other species are not tested.
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FORMULATION
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
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STORAGE
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
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Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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