Antigen Preparation
A recombinant protein of human TRIM29
Background
"zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. TRIM family proteins control important cellular processes such as intracellular signaling in innate immunity and viral infection, transcriptional regulation, development, autophagy, and carcinogenesis. TRIM29 a unique multifunctional protein for DNA damage responses, molecular cancer biomarker, cell adhesion/invasion in tumor cell differentiation and signal regulation for the canonical Wnt pathway. Current study shows thatTRIM29 promotes DNA virus infections by inhibiting innate immune response. Others demonstrate that TRIM29 regulates negatively the host innate immune response to RNA virus, which could be employed by RNA viruses for viral pathogenesis. It was confirmed recently that TRIM29 mediates lung squamous cell carcinoma cell metastasis by regulating autophagic degradation of E-cadherin."
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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