SOX-4
SRY (sex determining region Y)-box 4
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Antigen Preparation
"A synthetic peptide corresponding to the c-terminus (from 720AA-755aa) of human sox6 protein. This sequence is identical in human, mouse, rat, bovine, canis and chicken species."
Background
SOX6 gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. SOX6 protein is a transcriptional activator that is specifically expressed in the developing central nervous system and in the early stages of chondrogenesis in mouse embryos. It is found to be essential to both cartilage formation/chondrogenesis and obesity-related insulin resistance. The SOX6 protein is also detected in glioma patient sera and brain tissues.
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
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SPECIFICITY
"This antibody recognizes SOX4 protein. It cross-reacts to human, mouse, rat . The other species are not tested. "
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FORMULATION
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
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STORAGE
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
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Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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