Antigen Preparation
The full-length recombinant protein of human PPAR-alpha
Background
"The Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is a ligand activated transcription factor belonging to the nuclear receptor superfamily. PPARs bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. The PPAR-beta is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of PPAR-alpha is found to be associated to cancer cells. "
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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