STAT1
signal transducer and activator of transcription 1, 91kDa
Download Product PDF
MSDS Download Product PDF
Antigen Preparation
"A synthetic peptide surrounding to the C-terminus of STAT1 protein from human, mouse and rat origins."
Background
"STAT proteins (Signal transducer and activator of transcription) belong to a family of cytoplasmic transcription factors that can be phosphorylated by a lignad binding to its cell surface receptor. The phosphorylation of STAT1 at Tyr701 induces STAT1 dimerization, nuclear translocation and DNA binding. STAT 1 is activated by a number of different ligands, including IFN, EGF, PDGF and IL6. Tyrosine 701 phosphorylation impairment results in loss of STAT 1 functions. "
PURIFICATION
The Rabbit IgG is purified by Epitope Affinity Purification
|
SPECIFICITY
"This antibody recognizes STAT1 protein. It cross reacts with human, mice and rat."
|
FORMULATION
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
|
STORAGE
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
|
Applications/Suggested Working Dilutions
|
|
|
Immunoprecipitation
2-5 µg/ml
|
|
Flow cytometry
Not tested
|