Antigen Preparation
A synthetic peptide derived from C-terminus of human Cyclin A
Background
"Cyclin A belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. Cyclin A2 is expressed in dividing somatic cells. Increased expression of cyclin A2 has been observed in many types of cancer. Cyclin A2 was predicted as a potential differential marker of splenic diffuse red pulp small B-cell lymphoma. Studies indicate that cyclin A2 is a biomarker for the prognosis of ER+ breast cancer."
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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