Antigen Preparation
"A synthetic peptide derived from C-terminus of Glutamate receptor 6/7 Protein. This sequence is identical to human, mouse
and rat. "
Background
"Glutamate receptors (GluR) are the predominant excitatory neurotransmitter receptors in the mammalian brain and are
activated in a variety of normal neurophysiologic processes. Two classes of glutamate receptors exist: ionotropic receptors,
and metabotropic receptors. Ionotropic glutamate receptors are oligomeric complexes of various subunits (GluR1-7, NMDA1-
3, KAI-2), which comprise ligand-gated calcium channels. Metabotropic glutamate receptors are G-protein coupled
receptors. GluR6 belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as
ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first
and second transmembrane domains, which is thought to alter the structure and function of the receptor complex.
Mutations in this gene have been associated with autosomal recessive mental retardation. "
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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