Antigen Preparation
Synthetic peptide YGRNEVVSLMQANGAGG derived from human p18/INK4c.
Background
"P18/INK4c is a member of the INK4 family of cyclin-dependent kinase inhibitors. It interacts with CDK4 or CDK6, and prevent the activation of the CDK kinases, it is a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis."
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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