Androgen Receptor (AR) (pS210)
androgen receptor
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Antigen Preparation
"A synthetic peptide surrounding the epitope –EASGA- with a single phosphorylation site Ser210. This sequence is identical among human, rat, mouse, dog."
Background
"The androgen receptor (AR), a member of nuclear receptor family, is essential for the growth of prostate cancer cells. The phosphorylation of AR is induced by growth factors and elevated in hormone-refractory prostate tumors. It’s been reported the signal pathway of the PI3K/AKT, Src to be responsible for phosphorylation of AR at Ser213/210 and Ser81. The abnormal activation of AR is observed in many diseases, such as prostate cancer. "
PURIFICATION
The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
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SPECIFICITY
This antibody recognizes ~110 kDa of human AR protein. It also reacts with mouse and rat. The other species are not tested.
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FORMULATION
This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
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STORAGE
The antibodies are stable for 24 months from date of receipt when stored at –20oC to –70oC. The antibodies can be stored at 2oC-8oC for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
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Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
Not tested
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