Background
The cell adhesion molecule L1 (L1CAM) is an axonal glycoprotein which belongs to the immunoglobulin supergene family. The ectodomain,consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic raplegia and hydrocephalus). The malfunction of LaCAM may contribute to neurological and cancerous diseases.
Applications/Suggested Working Dilutions
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Immunoprecipitation
2-5 µg/ml
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Flow cytometry
5-10 µg/ml
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